外科与临床实践杂志

Innovations in an orphan disease: Male breast cancer

Atahan Acar

Male carcinoma (MBC) could be a very rare disease with a rising incidence in recent years. Although there are many similarities with carcinoma in women, some obvious differences have been shown. This speaking is aimed to draw attention with the present information of this rare entity. MBC could be a rare disease, accounting for less than 1% of all malignancies in men and for less than 1% of all incidents of breast carcinoma. Factors which are related to an increased risk are aging, case history of carcinoma, inherited gene mutations, Klinefelter syndrome, radiation exposure, alcoholic beverages intake, disease, estrogen treatment, obesity, physical inactivity, testicular conditions, and certain occupations. Although these factors may increase a man’s risks of developing carcinoma, the reason for most BMC is unknown. Most information on causes, prevention and treatment of carcinoma from clinical trials and research throughout the globe were worn out women. Recent studies concentrate on genetic testing totally on BRCA1 and BRCA2 mutations and also other genes that contribute to carcinoma risk also are being identified. Findings reveal that the results of genetic variations on the danger of carcinoma in men and ladies are different. New laboratory test as circulating tumour cells and also the effect of environment have also received more attention in recent years. More convenient ways of therapy and innovations in chemotherapy strategies by PARP (Poly ADP Ribose Polymerase) inhibitors and targeted therapies are quite popular. 2,470 newly diagnosed cases of invasive MBC were estimated by The American Cancer Society at the start of 2017 and also it had been estimated that 460 of them would die. of these improvements of this orphan disease is also will ready to save patients children from being orphans.
Atahan has completed his Graduation from grad School of Ankara University. He has completed General Surgery Residency at Ministry of Health, Ankara Numune Education and Research Hospital, Ankara, Turkey. He has served as a General Surgeon at Cankiri Ilgaz State Hospital and as a Surgeon and Head Physician at Burhaniye and Edremit State Hospitals at Balikesir Province. He’s working as a Specialist at the primary Department of Surgery, Izmir Katip Celebi University Ataturk Education and Research Hospital. He has received certificate of Fellowship in minimal access surgery at World Laparoscopy Hospital at Gurgaon, Haryana, India