遗传学与基因治疗杂志

Global MHC, Class I, Class II Genes in Invertebrates

Michel Leclerc

It appeared to be intriguing to sum up the discovered outcomes in Ophiocomina nigra and Antedon bifida(Echinodermata) according to a perspective of genomic advancement : 2 MHC class I genes(HLA-E, HLA-B), 2 MHC class II genes(HLA-DRB1, HLA-DQB1) appeared in them in the past (may be at the Cambrian period). As of late, it was demonstrated that, HLA-DRB1 quality existed in Ophiocomina nigra, so HLA-DQB1 quality . In a similar way we exhibited the presence of HLA-E, HLA-B qualities in Ophiocomina nigra and Antedon bifida . It was associated to the nearness of IPA (Invertebrate Primitive Antibody) in Echinodermata. . A reviewing of these works was assessed in this new paper."The capacity of MHC atoms is to tie peptide parts got from microorganisms and show them on the cell surface for acknowledgment by the proper T cells. The outcomes are quite often harmful to the microbe—infection tainted cells are executed, macrophages are actuated to eliminate microscopic organisms living in their intracellular vesicles, and B cells are enacted to create anti bodies that dispose of or kill extracellular microorganisms.