分子医学与治疗杂志

Parkinson’s Disease and Type-2 Diabetes: Methylglyoxal may be a Common Causal Agent; Carnosine could be Protective

Alan R. Hipkiss

Parkinson’s Disease and Type-2 Diabetes: Methylglyoxal may be a Common Causal Agent; Carnosine could be Protective

The likelihood that the type-2 diabetes influences the incidence of Parkinson’s disease (PD), via increased generation of methylglyoxal (MG), is examined in the light of recent evidence. Animal experiments (mice and dogs) have shown that high glycemic index diets increase tissue MG levels, while low glycemic index diets in humans are associated with a decreased incidence of PD. Proteomic studies have revealed an increased activity of the carnosinase, CNDP2, in the substantia nigra of PD patients.