耳鼻科杂志

The Effect of Paracetamol, Metamizole Sodium and Ketoprofen on Postoperative Hemorrhage Following Pediatric Tonsillectomy

Duran Karata?, Fatih Y�ksel and Murat Do?an

The Effect of Paracetamol, Metamizole Sodium and Ketoprofen on Postoperative Hemorrhage Following Pediatric Tonsillectomy

Aim: The aim of the present study was to determine the association between postoperative hemorrhage and using paracetamol, metamizole sodium and ketoprofen as analgesics after pediatric tonsillectomy.

Patients and Methods: 330 children with recurrent tonsillitis and/or obstructive symptoms were included in the present study. Children were divided into three groups based on the medicines used for postoperative pain. Each group was administered paracetamol, metamizole sodium or ketoprofen after the surgery. Study population was compared for postoperative hemorrhage. Chi-square test was used for statistical analysis.

Results: A total of 109 patients were administered ketoprofen while 110 patients received metamizole sodium and 111 patients received paracetamol. Post-tonsillectomy hemorrhage developed in 13 (3, 53) children among which there were three primary hemorrhage cases and one secondary hemorrhage case. Post-operative hemorrhage was observed in 5 (4, 36%) of the 109 cases receiving ketoprofen, in 4 (3, 64%) of the patients receiving metamizole sodium and in 4 (3, 57%) of the patients receiving paracetamol. There was no statistically significant difference with respect to hemorrhage rates among these three groups (p<0.05).

Conclusion: In our study, no significant increase was shown in hemorrhage risk after using ketoprofen, metamizole sodium and paracetamol, which suggests that these drugs can be used safely for post-tonsillectomy pain.