Lawrence S Amesse
The Fascinating World of Androgen Insensitivity Syndromes
The androgen insensitivity syndromes (AIS) comprise a fascinating group of X-linked recessive disorders of sex development (DSD), known collectively as 46 XY DSD. Since their identification as “testicular feminization syndrome” in 1953 by Dr. John Morris at Yale, significant technological advancements and refinements have heightened our understanding of the underlying molecular mechanisms that in part delineate the role of impaired of androgen responsiveness on the developing male fetus.
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