Elizabeth Blackwell
Desmoid tumors, also known as aggressive fibromatosis, are rare, benign soft tissue tumors characterized by their locally infiltrative nature and a propensity for recurrence. They arise from fibroblasts, the connective tissue cells responsible for producing collagen and extracellular matrix. Despite their benign histological appearance, desmoid tumors can present significant clinical challenges due to their tendency to invade surrounding tissues and organs, causing local morbidity and impacting patient quality of life. This article provides a comprehensive review of desmoid tumors, covering their etiology, clinical presentation, diagnostic approaches, treatment modalities, and management strategies. Recent advances in understanding their molecular pathogenesis and the evolving therapeutic landscape, including targeted therapies and surgical innovations, are also discussed. The aim is to enhance awareness and guide clinicians in the multidisciplinary management of these complex tumors.
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