药剂学与药物输送研究杂志

Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Nonenzymatic Antioxidants in Testes and Brain of Male Rats

Akintunde JK, Ajiboye JA, Siemuri EO, Oyelowo SB, Sunday OJ, Abam EO and Irondi AE

Sub-Chronic Treatment of Sildernafil Citrate (Viagra) on some Enzymatic and Nonenzymatic Antioxidants in Testes and Brain of Male Rats

Sildenafil citrate, a specific phosphodiesterase-5 (PDE-5) inhibitor drug currently used for the treatment of erectile dysfunction in men. The present study investigates the effects of Sildenafil citrate on antioxidant defense systems of testes and brain tissues of male rats by measuring the GSH, SOD, and CAT activity. Lipid peroxidation was also estimated by measuring the MDA levels, a Thiobarbituric Acid Reactive Substrate (TBARS) as biomarker of oxidative stress. Sildenafil citrate was orally administered at the different dose levels of 20 mg/kg body weight per 30 days in four divided doses of 50, 100, 150 and 200 mg/kg body weight while control rats were given distilled water.