药物科学与新兴药物杂志

Synthesis, Characterization and Biological Elucidation of Mixed Ligand Cu(II) Complexes as Artificial Metallonucleases

Mohan N Patel, Parag S Karia, Pankaj A Vekariya and Anshul P Patidar

Synthesis, Characterization and Biological Elucidation of Mixed Ligand Cu(II) Complexes as Artificial Metallonucleases

Bipyridines (L1–L7) derived from reaction between chalcones and pyridinium salt have been synthesized and characterized by IR, 1H–NMR and 13C–NMR techniques. The synthesized ligands have been screened for their antibacterial and DNA binding activities. Subsequently their complexes have been synthesized with CuCl2•2H2O and ofloxacin and characterized by elemental analysis, magnetic moment measurement, thermal analysis (TG), IR, LC–MS and electronic spectra. Antibacterial activity of complexes has been elucidated in terms of MIC values. Absorption titration, viscosity measurement and gel electrophoresis techniques have been performed to examine the base specific interaction of Cu(II) complexes with DNA. Result shows efficient DNA binding and cleavage ability of synthesized Cu(II) complexes compared to the reference drug and bipyridine derivatives.