应用生物信息学与计算生物学杂志

Finite Element Method Approach for Thermal Analysis of Female Breast Tissue Tumor Model

Sharmila Shrestha and Dil Bahadur Gurung

Breast cancer is one of the leading cancer and the second leading cause of death in women worldwide. It can occur when cancer develops in breast tumor. The tumor tissue has generally higher metabolic and blood perfusion rate than normal tissue. It then causes the temperature rise in the in-vivo breast tissue. Previous researchers have studied the temperature profiles on the breast skin surface only with and without tumor. The aim of the present work is to study the temperature distribution profiles in the layers of breast tissue with and without tumor along the direction from aerola to the body core. Breast tumor can be occurred in any layers of breast tissue but most of the cancer cells are normally developed in glandular layer. So, the study is carried out based on the tumor in glandular layer. Pennes bio-heat equation is used to study the temperature variation in the layers of breast tissue. In the study, it is observed that the location and size of the tumor has significant effect on the breast tissue temperature.