内分泌学和糖尿病研究

Comparison of Lipid Profile in Diabetic Patients taking Oral Hypoglycemic Drugs Versus Insulin Therapy

Rizwan Munir* ,Zahid Hussain Shah, Ahsan Mushtaq, Hafiz Sajid, Umer Sohail

Background: Diabetes mellitus is the most prevalent disease all around the world. Medication can be prescribed as insulin and oral anti-glycemic. There is also significant impact of diabetic therapy on lipid profile of diabetic patients. Objective: To compare lipid profile of diabetic patients taking oral hypoglycemic drugs versus insulin therapy.

Study design: Quasi experimental study.

Materials and Methods: 70 newly diagnosed cases of diabetes, were recruited and divided in 2 groups. Patients who were prescribed insulin were assigned as group A while patient who were prescribed oral anti-glycemic were assigned as group B. The patients were followed for 3 months for serum lipid profile and findings of the lab were noted on proforma. The collected data was analyzed by SPSS-23. Both groups were compared by using student t test at the level of significance ≤ 0.05.

Results: In this study, the mean age of patients was 46.77 years ± 14.80 years in patients taking insulin while 46.89 years ± 14.57 years in oral anti-glycemic group. In patients taking insulin, there were 20 (57.1%) males and 15 (42.9%) females. In oral anti-glycemic group, there were 20 (57.1%) males and 15 (42.9%) females. After 3 months of anti-glycemic course, mean total cholesterol level was 211.74 mg/dl ± 27.59 mg/dl versus 292.97 mg/dl ± 49.72 mg/dl, mean triglycerides level was 216.89 mg/dl ± 50.29 mg/dl versus 262.69 ± 72.33 mg/dl, mean LDL level was 163.34 ± 22.47 mg/dl versus 196.00 ± 24.70 mg/dl and mean HDL level was 48.91 mg/dl ± 9.27 mg/dl versus 46.31 ± 5.14 mg/dl in patients taking insulin therapy versus oral anti-glycemic respectively. Conclusion: We observed through this trial that the lipid profile of patient taking insulin therapy is more under controlled than patients taking oral anti-glycemic medication.

Conclusion: We observed through this trial that the lipid profile of patient taking insulin therapy is more under controlled than patients taking oral anti-glycemic medication.