Hyunsook Kim、Jihye Kwan、Yun-ju Cho、Dong-Hyun Kim、Hong-seok Kim 和 Kun-Ho Seo
本研究的目的是确定益生元（全葡萄籽粉）和益生菌（开菲尔乳酸菌，LAB）的混合物是否能产生协同合生元，对抗肥胖小鼠的肥胖影响。葡萄籽富含多酚，包括黄酮醇，尤其是原花青素。小鼠接受高脂肪（HF，47% 脂肪热量）或普通饮食喂养五周。HF 饮食的小鼠体重比普通饮食的小鼠更重，这被视为饮食诱导黑啤酒 (DIO)。DIO 小鼠接受 HF 或 HF 饮食喂养，HF 饮食中加入了 5% 或 10% 的霞多丽葡萄籽 (ChrSd) 粉和开菲尔乳酸菌混合物，喂养时间约为两个月。继续维持富含 ChrSd 和 LAB 的 HF 饮食可显著降低体重增加、肝脏重量、脂肪重量以及血浆和肝脏脂质水平。ChrSd 和 LAB 共同改善了胰岛素敏感性。这些变化在 ChrSd 和 LAB 的结合下更为显著。可能因素可能与肠道中益生菌乳酸菌的作用导致原花青素的生物利用度提高有关。这些结果表明，ChrSd 和 LAB 的联合作用可有效降低 HF 引起的肥胖和胰岛素抵抗。这些协同作用可以解决大量益生元或益生菌消费需要产生类似健康有益影响的问题。
Adjustments of intestinal microbiota by synbiotic activity of pre-and probiotics may give medical advantages to the host. In this investigation, high-throughput sequencing of 16S rRNA was utilized to break down intestinal microbiota in excrement, and the overall wealth of intestinal microscopic organisms was connected with physiological information from an earlier investigation of a synbiotic blend of flavonoid-rich wine grape seed flour (WGF) and two recently confined kefir lactic corrosive microorganisms (LAB) in diet-initiated stout mice. The blend of WGF and LAB improved watched operational ordered units and Chao1 file contrasted with WGF alone, demonstrating an expansion in the microbial network extravagance. The mix fundamentally upgraded wealth of Akkermansia muciniphila and Nocardia coeliaca and their bounty had an opposite relationship with body weight put on and fat weight. Taking everything into account, the synbiotic impacts of WGF and LAB on progress of high-fat-diet-instigated corpulence are firmly connected to redesigning intestinal microbiota. There is a noteworthy decrease of body weight addition and liver loads, plasma insulin focuses, and HOMA-IR in every single trial bunch contrasted with control. All out lipid substance, triglyceride, and low-thickness lipoprotein (LDL)- cholesterol centralizations of the liver are additionally altogether brought down. The mix of GSF and LAB further fundamentally influences cecum propionate content, plasma aspartate aminotransferase (AST/GOT), and zonulin fixations, which is essentially connected with hepatic lipid content. Examination of hepatic microarray information uncovers that qualities identified with lipid blend, bile corrosive and cholesterol union, cancer prevention agent exercises, oxidative pressure, aggravation, and liver capacity are fundamentally balanced after the mix of GSF and LAB. End: These information recommend that improvement of HF-prompted hepatic steatosis after utilization of GSF and LAB is somewhat interceded by means of change of cecum propionate and intestinal porousness, which balances hepatic quality articulation. Pre-birth dexamethasone (DEX) introduction and high-fat (HF) admission are connected to hypertension. We inspected whether maternal melatonin treatment forestalls customized hypertension synergistically instigated by pre-birth DEX in addition to postnatal HF in grown-up posterity. We additionally analyzed whether DEX and melatonin causes renal programming utilizing cutting edge RNA sequencing (NGS) innovation. Pregnant Sprague-Dawley rodents got intraperitoneal dexamethasone (0.1 mg/kg) or vehicle from gestational day 16 to 22.
血压显著升高，血清中的脂质谱（包括甘油三酯、总胆固醇、LDL 胆固醇和 HDL 胆固醇）显著降低。此外，肝脏损伤表现为血清中的丙氨酸转氨酶 (ALT) 和天冬氨酸转氨酶 (AST) 大幅增加。RPA 提取物显著扭转了这些参数，表明它可以减轻啮齿动物的肝脏损伤。在 SHR 中，我们的结果表明，RPA 提取物的抗高血压作用可能与其对控制血清一氧化氮 (NO) 和内皮素 (ET) 水平的影响有关。
English 
Spanish 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi